10TH ANNUAL SCIENTIFIC SYMPOSIUM AGENDA
May 23 – 25, 2023 | Cleveland, Ohio
Have a question? Email Questions@HarringtonDiscovery.org
Tuesday, May 23 – Day One
Harrington Scholar Programming: 6:00 PM – 8:00 PM ET BY INVITATION ONLY
6:00 PM -
8:00 PM
Casual Scholar Reception & Dinner
By Invitation Only
Wednesday, May 24 – Day Two
Keynote Address & Reception: 4:00 PM – 6:15 PM ET OPEN TO ALL GUESTS
Harrington Scholar Programming: 7:30 AM – 8:45 PM ET BY INVITATION ONLY
8:00 AM -
2:50 PM
Scholar Project Team Meetings
By Invitation Only
8:30 AM –
9:30 AM
Scholar Workshop One
Presented by Jim Bryson, PhD & William Greenlee, PhD
Title: Target Compound Profiles for Drug Discovery
A Target Compound Profile is a set of desired properties of a molecule expected to be met at a defined stage of a Scholar program. Harrington Discovery Institute has created formats for Target Compound Profiles for both small molecules and large molecules. These documents help support decisions about advancing and resourcing Scholar programs and ensure that team members have a common understanding of the profiles required for success. In this presentation, we will present and discuss sample profiles for hits, leads, development candidates and products.
10:00 AM –
11:00 AM
Scholar Workshop Two
Presented by Bernard Cambou, PhD, MBA & Jan Rosenbaum, PhD
Title: How to Best Position Your Novel Drug Opportunity to Attract “Commercial” Interest
The mission of Harrington Discovery Institute’s Scholar Award programs is to advance academic discoveries in areas of unmet therapeutic need into medicines for the benefit of society. In order to do that, scientists must not only be developing disruptive therapies, but should also be able to communicate their value proposition to investors and partners who will be able to help bring those therapies to market. In this workshop, we will discuss the elements of the value proposition, how to de-risk the development plan from target validation through clinical development. We hope to encourage academic investigators to present their value proposition to investors and commercial partners in the context of multi-level differentiating factors.
11:00 AM –
2:00 PM
Poster Session
By Invitation Only
4:00 PM -
6:15 PM
6:30 PM -
8:45 PM
Keynote Address & Reception
Open to All Guests
Tinkham Veale University Center
Ballroom A/B on Floor 2
Jean Bennett, MD, PhD
University of Pennsylvania
2023 Harrington Prize Co-Recipient
Title: Genes as Medicine: From Concept to Practice
Private Dinner & Remarks
By Invitation Only
Robert Lefkowitz, MD
Duke University Medical Center
Thursday, May 25 – Day Three
Harrington Scholar Programming: 7:30 AM – 4:25 PM ET BY INVITATION ONLY
7:30 AM -
8:30 AM
Continental Breakfast
By Invitation Only
8:30 AM -
11:45 AM
8:45 AM -
9:43 AM
Scholar Presentations (PRIVATE SESSION)
By Invitation Only
Li Lan, MD, PhD
Massachusetts General Hospital
Title: Targeting mRNA Methyltransferase in Cancer Therapy
Loren Walensky, MD, PhD
Dana-Farber Cancer Institute
Title: Multimodal Targeting of Chemo-Resistant Cancer by Stapled Peptide PROTACs
Carolyn Lee, MD, PhD
Stanford University
Title: Design, Synthesis and Validation of Novel RET Inhibitors to Treat Cutaneous Squamous Cell Carcinoma
9:45 AM -
10:20 AM
Break
10:25 AM -
11:43 AM
Bernd Schnabl, MD
University of California, San Diego
Title: Bacteriophage Therapy to Treat Alcoholic Hepatitis
James Hagood, MD
University of North Carolina
Title: Thy-1 Molecular Mimicry as a Therapeutic Strategy for Pulmonary Fibrosis
Burton Dickey, MD
University of Texas MD Anderson Cancer Center
Title: Targeting Syt2 to Prevent Airway Mucin Hypersecretion
12:00 PM -
1:30 PM
2:12 PM -
4:20 PM
Luncheon & Presentation
By Invitation Only
Scholar Presentations (PRIVATE SESSION)
By Invitation Only
2:12 PM -
3:10 PM
Diana Farmer, MD
University of California, Davis
Title: Engineered Human Placenta-Derived Mesenchymal Stem / Stromal Cells for the Treatment of Acquired Spinal Cord Injury
Ed Grabczyk, PhD
LSU Health Sciences Center in New Orleans
Title: Small Molecule Induced Skipping of MLH3 Exon Seven to Slow Progression of DNA Repeat Expansion Disorders
Michael Lin, MD, PhD
Stanford University
Title: Potent and Selective Protease Inhibitors for Treatment of COVID-19 and Future Coronavirus Diseases
3:12 PM -
3:20 PM
Stretch Break
3:22 PM -
4:20 PM
David Myung, MD, PhD
Stanford University
Title: Regenerative Matrix Therapy for the Cornea
Xin Qi, PhD
Case Western Reserve University
Title: Development of ATAD3A Peptide Inhibitors to Treat Alzheimer’s Disease
Nabil Alkayed, MD, PhD
Oregon Health and Science University
Title: GPR39 as a Therapeutic Target in Vascular Cognitive Impairment and Dementia (VCID)
4:20 PM -
4:25 PM
Closing Remarks
Seth Field, MD, PhD
