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11TH ANNUAL SCIENTIFIC SYMPOSIUM 
May 21 – 23, 2024 | Cleveland, Ohio

Have a question? Email Questions@HarringtonDiscovery.org

AGENDA
*Sessions are by invitation only unless otherwise indicated

Tuesday, May 21 – Pre-Symposium

6:00 PM -

8:00 PM

CASUAL SCHOLAR RECEPTION & DINNER

Bar 32, Hilton Cleveland Downtown

Wednesday, May 22 – Pre-Symposium

7:30 AM -

8:30 AM

BREAKFAST BUFFET

Hilton Cleveland Downtown / Superior A Ballroom Floor 5

8:00 AM -

2:50 PM

SCHOLAR PROJECT TEAM MEETINGS

Hilton Cleveland Downtown

8:30 AM –

9:30 AM

SCHOLAR WORKSHOP 

Hilton Cleveland Downtown

Topic: Chemical Principles of Drug Action in vivo and Guidelines for Brain Access

Presented by: Peter Bernstein, PhD and George Trainor, PhD, Harrington Discovery Institute Therapeutics Development Center 

 

This workshop will cover two related topics in drug discovery and development. First, George Trainor will describe the Chemical Principles of Drug Action In Vivo. The Free Drug Principle will be used to explain why some agents that bind tightly to specific molecular targets are not effective in vivo. Kpu,u will follow as the way to measure effective brain levels. Then Peter Bernstein will describe the barriers that make accessing the CNS different. He will review the in vitro assays known to predict CNS access in vivo and discuss tools and guidelines for designing in the properties needed to achieve good brain access.

10:00 AM –

11:00 AM

SCHOLAR WORKSHOP 

Hilton Cleveland Downtown

Topic: Funding in Today’s Environment: Maximizing Your Chances for Success

Presented by: Rahul Aras, PhD and Daniel Burke

12:00 PM -

1:00 PM

LUNCH BUFFET

Hilton Cleveland Downtown / Superior A Ballroom Floor 5

Wednesday, May 22 – Symposium Day One

4:00 PM -

6:15 PM

PLENARY SESSION 

Open to All Guests

Cleveland Museum of Natural History

Murch Auditorium

KEYNOTE

Daniel Skovronsky, MD, PhD

Executive Vice President; Chief Scientific Officer and President, Lilly Research Laboratories; President, Immunology, Eli Lilly and Company

Title: Harnessing Incretin Biology to Improve Human Health

   Click for Bio   

HARRINGTON SCHOLAR EXPERIENCE

Ed Grabczyk, PhD

2018 Harrington Rare Disease Scholar

LSU Health Sciences Center

   Click for Bio   

RECEPTION

Cleveland Museum of Natural History

Fawick Gallery / Visitor Hall

6:30 PM -

8:45 PM

DINNER & HARRINGTON PRIZE

Severance Hall / Grand Foyer

Arlene Sharpe, MD, PhD

2024 Harrington Prize Recipient

Kolokotrones University Professor and Chair of the Department of Immunology

Harvard Medical School

Title: Reflections

   Click for Bio   

Thursday, May 23 – Symposium Day Two

7:30 AM -

8:30 AM

CONTINENTAL BREAKFAST

Cleveland Institute of Music / Pogue Lobby

8:30 AM -

11:45 AM

SCHOLAR SCIENTIFIC PRESENTATIONS MORNING SESSION

Cleveland Institute of Music / Mixon Hall 

8:45 AM -

9:45 AM

Loren Walensky, MD, PhD

Dana-Farber Cancer Institute

Title: Multimodal Targeting of Chemo-Resistant Cancer by 

Stapled Peptide PROTACs

   Click for Bio   

Li Lan, MD, PhD 

Massachusetts General Hospital

Title: Targeting mRNA Methyltransferase in Cancer Therapy

   Click for Bio   

Hans-Guido Wendel, MD, PhD

Memorial Sloan Kettering Cancer Center

Title: Blocking MYC Protein Production in Cancer

   Click for Bio   

9:45 AM -

10:20 AM

BREAK

10:25 AM -

11:45 AM

Christiane Wrann, DVM, PhD

Massachusetts General Hospital

Title: Irisin-Leveraging Exercise to Improve Cognitive Function

in Alzheimer’s Disease

   Click for Bio   

Bernd Schnabl, MD 

University of California, San Diego

Title: Bacteriophage Therapy to Treat Alcohol-Associated Hepatitis

   Click for Bio   

Michael Lin, MD, PhD

Stanford University

Title: Potent and Selective Protease Inhibitors for Treatment of COVID-19 and Future Coronavirus Diseases

   Click for Bio   

Carolyn Lee, MD, PhD

Stanford University

Title: Design, Synthesis and Validation of Novel RET

Inhibitors to Treat Cutaneous Squamous Cell Carcinoma

   Click for Bio   

11:45 AM -

11:55 AM

WALK TO CLEVELAND BOTANICAL GARDEN

12:00 PM -

1:30 PM

LUNCHEON & PRESENTATION

Cleveland Botanical Garden / Woodland Hall

Refreshments on the patio

Ali Rezai, MD

Executive Director, WVU Rockefeller Neuroscience Institute

John D. Rockefeller IV Chair in Neuroscience

Title: Focused Ultrasound: Breaking Barriers in Neurotherapeutics

   Click for Bio   

2:15 PM -

4:15 PM

SCHOLAR SCIENTIFIC PRESENTATION AFTERNOON SESSION

Cleveland Institute of Music / Mixon Hall 

2:15 PM -

3:13 PM

James Hagood, MD

University of North Carolina

Title: Thy-1 Molecular Mimicry as a Therapeutic Strategy for Pulmonary Fibrosis

   Click for Bio   

Francis McCormack, MD 

University of Cincinnati

Title: An Improved Method of Pleurodesis: PAM Suggests HAM for LAM

   Click for Bio   

Burton Dickey, MD

University of Texas MD Anderson Cancer Center

Title: Targeting Syt2 to Prevent Airway Mucin Hypersecretion

   Click for Bio   

3:15 PM -

3:30 PM

BREAK

3:35 PM -

4:13 PM

Laura Blair, PhD

University of South Florida

Title: An Aha(1) Disrupter for Tauopathies

   Click for Bio   

Diana Farmer, MD 

University of California, Davis

Title: Engineered Human Placenta-Derived Mesenchymal Stem / Stromal Cells for the Treatment of Congenital and Acquired Spinal Cord Injury

   Click for Bio   

4:15 PM -

4:20 PM

CLOSING REMARKS

Seth Field, MD, PhD

RESOURCE CENTER

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