10:00am –10:15am

Welcome

Jonathan S. Stamler, MD

President, Harrington Discovery Institute

Robert S. & Sylvia K. Reitman Family Foundation Distinguished Chair in Cardiovascular Innovation

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Introduction to Ronald G. Harrington

Daniel I. Simon, MD

President, Academic & External Affairs and Chief Clinical & Scientific Officer, University Hospitals 
Ernie and Patti Novak Distinguished Chair in Health Care Leadership at University Hospitals

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Remarks

Ronald G. Harrington

Philanthropist and Entrepreneur​

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10:15am –10:50am

Introduction to Keynote Address

Jonathan S. Stamler, MD

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Keynote Address

Jeffrey Leiden, MD, PhD

Title: Discovering Transformative Medicines: The Vertex Innovation Model

Executive Chairman, Vertex Pharmaceuticals

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10:50am –11:00am

Introduction of Cliff Megerian, MD 

Jonathan S. Stamler, MD

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UH Remarks

Cliff A. Megerian, MD, FACS

CEO, University Hospitals

Jane and Henry Meyer Chief Executive Officer Distinguished Chair

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11:00am –11:45am

The Harrington Impact on Alzheimer’s Disease:

Novel Pathways and Therapies

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Moderator:

Andrew Pieper, MD, PhD

Director, Center for Brain Health Medicines, Harrington Discovery Institute

Investigator, Harrington Discovery Institute

Morley-Mather Chair in Neuropsychiatry

Panel Members:

Jerri Rook, PhD

Vanderbilt University

2015 ADDF-Harrington Scholar

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Stephen Strittmatter, MD, PhD 

Yale University

2020 Harrington Scholar-Innovator

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Jonathan Stamler, MD

Case Western Reserve University / University Hospitals

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11:45am –12:10pm

Introduction of 2022 Harrington Prize Recipients

Hossein Ardehali, MD, PhD

Northwestern University

President, American Society for Clinical Investigation

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2022 Harrington Prize Remarks

James Crowe, MD

Vanderbilt University

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Michel Nussenzweig, MD, PhD

The Rockefeller University

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12:15pm –12:30pm

12:30pm –12:35pm

Introduction to Scholar Presentations and Advisory Panels

Moderator:

Seth Field, MD, PhD

Director, Physician-Scientist Programs

Investigator, Harrington Discovery Institute

12:35pm –3:00pm

Rizwan Haq, MD, PhD

Title: A Small Molecule that Targets Cancers with Dysregulated KEAP-NRF2 Signaling

2020 Harrington Scholar-Innovator

Dana-Farber Cancer Institute

Jill Smith, MD

Title: Targeted Nanoparticle for Early Diagnosis and Treatment of Pancreatic Cancer

2021 Harrington Scholar-Innovator

Georgetown University

Joseph Contessa, MD, PhD

Title: Development of OST Inhibitors for the Treatment of Lung Cancer

2021 Harrington Scholar-Innovator

Yale University

John Chorba, MD

Title: Inhibiting PCSK9 Self-Proteolysis to Treat Atherosclerosis

2021 Harrington Scholar-Innovator

University of California, San Francisco

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Kyu Rhee, MD, PhD

Title: Pantothenamides Against Tuberculosis: Selective Inhibitors of the Mycobacterium Tuberculosis Tubercle

2020 Harrington Scholar-Innovator

Weill Cornell Medicine

Jennifer Chen, MD

Title: Targeting Acid Ceramidase to Reverse Fibrosis

2021 Harrington Scholar-Innovator

University of California, San Francisco

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Aaron Schimmer, MD

Title: Development of Novel Inhibitors of Human Mitochondrial Protease, ClpP

2021 Harrington Scholar-Innovator

University of Toronto

3:00pm 

Day 1 Closing Remarks

Seth Field, MD, PhD

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10:00am –10:10am

Welcome Back

Seth Field, MD, PhD

Director, Physician-Scientist Programs

Investigator, Harrington Discovery Institute

10:10am –10:35am

Introduction to Scholar Experience Presentations

Diana Wetmore, PhD

Vice President of Therapeutics Development, Harrington Discovery Institute

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Rosa Bacchetta, MD

Stanford University

2019 Harrington Scholar-Innovator

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Marc Wein, MD, PhD

Massachusetts General Hospital

2018 Harrington Scholar-Innovator

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10:35am –11:25am

Introduction to Panel Session 

Lenka Fedorkova, PhD

Vice President, Business Development and Strategic Alliance Management

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Creating a Value Proposition that Attracts Investment:

A Panel Session with Harrington Investment Advisors

Moderator:

Rebecca Braun

Consultant, Harrington Discovery Institute

Panel Members:

Graeme Martin, PhD

Chief Investment Officer, ALSA Ventures

Member, Harrington Discovery Institute Investment Advisory Board

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John Rice, PhD

Life Sciences Managing Director, CincyTech, LLC.

Chair, Harrington Discovery Institute Investment Advisory Board

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Jesse Treu, PhD

Partner Emeritus, Domain Associates

Member, Harrington Discovery Institute Investment Advisory Board

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11:25am –12:00pm

BREAK & END OF DAY 2 PLENARY SESSION

12:00pm –12:05pm

Introduction to Scholar Presentations and Advisory Panels

Moderators:

Andrew Pieper, MD, PhD

Director, Center for Brain Health Medicines, Harrington Discovery Institute

Investigator, Harrington Discovery Institute

Morley-Mather Chair in Neuropsychiatry

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Atul Chopra, MD, PhD

Investigator, Harrington Discovery Institute

12:05pm –2:10pm

Stephen Martin, PhD

Title: New Approach for Neuroprotection of Photoreceptors by Targeting TMEM97/σ2R

2019 Gund Harrington Scholar

University of Texas at Austin

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Donald Weaver, MD, PhD, FRCP(C)

Title: Design and Development of Small Molecular Therapeutics Targeting the Immunopathy of Alzheimer’s Disease

2020 Harrington Scholar-Innovator

University Health Network

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Xinnan Wang, MD, PhD

Title: Targeting Mitophagy for Treating Parkinson’s Disease

2021 Harrington Scholar-Innovator

Stanford University

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Timothy Yu, MD, PhD

Title: ASO Treatment for KCNT1-Associated Developmental Epileptic Encephalopathy

2020 Harrington Scholar-Innovator

Boston Children's Hospital

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Michael Holtzman, MD

Title: A New Drug to Correct Epithelial Stem Cell Reprogramming in Respiratory Disease

2020 Harrington Scholar-Innovator

Washington University St. Louis

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Toren Finkel, MD, PhD

Title: Generating Small Molecules that Boost NAD+ Levels for Age-Related Diseases

2021 Harrington Scholar-Innovator

University of Pittsburgh

2:10pm 

Day 2 Closing Remarks

Jonathan S. Stamler, MD

President, Harrington Discovery Institute

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